68 27 193 5 464 document 193 HoxA4 alignment.fas text/plain a437d2cdf5d38d025fc9de5192d04d14 MD5 5770 2015-01-14 09:55:17 https://data.ub.uni-muenchen.de/68/1/HoxA4%20alignment.fas 68 1 1 text/plain other alignment de public

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supplemental 194 5 466 document 194 HoxA5 alignment.fas text/plain e1b2b863bf4f6e0c7e15b3d3d21a11d4 MD5 5924 2015-01-14 09:55:21 https://data.ub.uni-muenchen.de/68/2/HoxA5%20alignment.fas 68 2 2 text/plain other alignment de public

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supplemental 195 5 468 document 195 HoxB4 alignment.fas text/plain 281cfd721c86265bf30752d838d2d061 MD5 8135 2015-01-14 09:55:25 https://data.ub.uni-muenchen.de/68/3/HoxB4%20alignment.fas 68 3 3 text/plain other alignment de public

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supplemental 196 5 470 document 196 HoxB7 alignment.fas text/plain fa4a730278ddb2ab837ea852841c0621 MD5 5405 2015-01-14 09:55:30 https://data.ub.uni-muenchen.de/68/4/HoxB7%20alignment.fas 68 4 4 text/plain other alignment de public

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supplemental 197 5 472 document 197 HoxB8 alignment.fas text/plain 50df1435873bd4927f288053b9a8597d MD5 8294 2015-01-14 09:55:37 https://data.ub.uni-muenchen.de/68/5/HoxB8%20alignment.fas 68 5 5 text/plain other alignment de public

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supplemental 198 5 474 document 198 HoxC4 alignment.fas text/plain 82b3d4776e25aaca273b7687ecde9cce MD5 6271 2015-01-14 09:55:44 https://data.ub.uni-muenchen.de/68/6/HoxC4%20alignment.fas 68 6 6 text/plain other alignment de public

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supplemental 199 5 476 document 199 HoxC5 alignment.fas text/plain f8f47728731147ef15a0143149acff3d MD5 8551 2015-01-14 09:55:48 https://data.ub.uni-muenchen.de/68/7/HoxC5%20alignment.fas 68 7 7 text/plain other alignment de public

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supplemental 200 5 478 document 200 HoxC6 alignment.fas text/plain 8703771288027b35a425d1eabc552788 MD5 5014 2015-01-14 09:55:55 https://data.ub.uni-muenchen.de/68/8/HoxC6%20alignment.fas 68 8 8 text/plain other alignment de public

HoxC6 alignment.fas

supplemental 201 5 480 document 201 HoxC8 alignment.fas text/plain d023f5e7fa7cdd38e9adcc322265b70e MD5 8117 2015-01-14 09:55:57 https://data.ub.uni-muenchen.de/68/9/HoxC8%20alignment.fas 68 9 9 text/plain other alignment de public

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supplemental 202 5 482 document 202 HoxD4 alignment.fas text/plain 39181bc1628feb4f5bdefa5cb690d374 MD5 8237 2015-01-14 09:56:00 https://data.ub.uni-muenchen.de/68/10/HoxD4%20alignment.fas 68 10 10 text/plain other alignment de public

HoxD4 alignment.fas

supplemental archive 149 http://dx.doi.org/10.1098/rspb.2015.0077 disk0/00/00/00/68 2015-06-16 11:07:03 2021-02-08 16:00:27 2015-06-16 11:07:03 data show The relationship between developmental genes and phenotypic variation is of central interest in evolutionary biology. An excellent example is the role of Hox genes in the anteroposterior regionalization of the vertebral column in vertebrates. Archosaurs (crocodiles, dinosaurs including birds) are highly variable both in vertebral morphology and number. Nevertheless, equivalent Hox genes are active in the axial skeleton during embryonic development, indicating that the morphological variation across taxa is likely due to modifications in the pattern of Hox gene expression. By using geometric morphometrics, we here demonstrate a direct correlation between vertebral Hox code and quantifiable vertebral morphology in modern archosaurs, in which the boundaries between morphological subgroups of vertebrae can be linked to anterior Hox gene expression boundaries. Our findings reveal homologous units of cervical vertebrae in modern archosaurs, each with their specific Hox gene pattern, enabling us to trace these homologies in the extinct sauropodomorph dinosaurs, a group with highly variable vertebral counts. Based on the quantifiable vertebral morphology, this allows us to infer the underlying genetic mechanisms in vertebral evolution in fossils, which represents not only an important case study of evolutionary biology, but will lead to a better understanding of the origin of morphological disparity in recent archosaur vertebral columns. eng Böhmer Christine Rauhut Oliver Wörheide Gert 2013-12 500 560 10.5282/ubm/data.68 https://doi.org/10.5282/ubm/data.68 public axial skeleton evolution sauropodomorph dinosaurs regulatory genes phenotypic variation none Böhmer Christine Supplementary data from Böhmer C, Rauhut OWM, Wörheide G. 2015 Correlation between Hox code and vertebral morphology in archosaurs. Proc. R. Soc. B 20150077. http://dx.doi.org/10.1098/rspb.2015.0077 fak20