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other archive 1179 disk0/00/00/06/26 2025-06-06 14:18:48 2025-06-06 14:19:10 2025-06-06 14:18:48 data show The attached supplemental data has been used for the following preprint: https://doi.org/10.1101/2024.12.15.628103 Detailed description of data collection, aggregation and analysis can be found in the publication. Abstract: Experimental mouse models are indispensable for the preclinical development of cancer immunotherapies, whereby complex interactions in the tumor microenvironment (TME) can be somewhat replicated. Despite the availability of diverse models, their predictive capacity for clinical outcomes remains largely unknown, posing a hurdle in the translation from preclinical to clinical success. This study systematically reviews and meta-analyzes clinical trials of chimeric antigen receptor (CAR)-T cell monotherapies with their corresponding preclinical studies. Adhering to PRISMA guidelines, a comprehensive search of PubMed and ClinicalTrials.gov was conducted, identifying 422 clinical trials and 3157 preclinical studies. From these, 105 clinical trials and 180 preclinical studies, accounting for 44 and 131 distinct CAR constructs, respectively, were included. Patients’ responses varied based on the target antigen, expectedly with higher efficacy and toxicity rates in hematological cancers. Preclinical data analysis revealed homogenous and antigen-independent efficacy rates. Our analysis revealed that only 4 % (n = 12) of mouse studies used syngeneic models, highlighting their scarcity in research. Three logistic regression models were trained on CAR structures, tumor entities, and experimental settings to predict treatment outcomes. While the logistic regression model accurately predicted clinical outcomes based on clinical or preclinical features (Macro F1 and AUC > 0.8), it failed in predicting preclinical outcomes from preclinical features (Macro F1 < 0.5, AUC < 0.6), indicating that preclinical studies may be influenced by experimental factors not accounted for in the model. These findings underscore the need to better understand the experimental factors enhancing the predictive accuracy of mouse models in preclinical settings. eng Andreu Sanz David Gregor Lisa Carlini Emanuele Kobold Sebastian 2025-06-06 500 570 610 10.5282/ubm/data.626 https://doi.org/10.5282/ubm/data.626 public en cc-by-nc Kobold Sebastian fak07